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Hexafluoroisopropanol (abbreviation: HFIP), the molecular formula is C3H2F6O, is a viscous, colorless liquid with a pungent odor.
Although HFIP has a certain viscosity but its boiling point is very low, it usually needs to be analyzed at 40°C to reduce the back pressure of the column.
Hexafluoroisopropanol is also a highly polar solvent, which can make calibration curves for mixed-bed columns non-linear.
Hexafluoroisopropanol is a volatile (boiling point 58.2°C) and polar substance with high density, low viscosity and low surface tension
Therefore, Agilent has developed a special column for Hexafluoroisopropanol solvent – PLHFIPgel column, which has a porous structure that is not affected by the solvent.