Domperidone paramete

CAS No.: 57808-66-9
MF: C22H24ClN5O2
Place of Origin: Shandong, China
Grade Standard: Medicine Grade, Medicine Grade
Brand Name: LOOK cas 57808-66-9
Purity: 99%min, 99.0%min
CAS: 57808-66-9
Packing: 25kg/net drum or 1kg/aluminum foil bag
Solubility: DMSO 40 mg/mL
form: powder
Other Names: Domperidone
EINECS No.: 260-968-7
Type: Gastrointestinal Agents
Usage: Animal Pharmaceuticals
Model Number: ELLEN
Product name: Domperidone
Color: White powder
Molecular Weight: 425.91
Long-term Storage: at -20℃


Items Requirements Results
Appearance White to off white powder White powder
Solubility Practically insoluble in water, soluble in dimethylformamide,  slightly soluble in ethanol(96%) and in methanol Confirms
Identification A. M.P. 244~248℃ 244.5~245.5℃
B. IR should comply Confirms
C. TLC should comply Confirms
D. It gives the reaction of non-nitrogen substituted barbiturates. Confirms
Clarity of solution The solution is clear and not more intensely colored than  reference solution Y6 Confirms
Related substance Total impurities≤0.5% ≤0.29%

Individual impurity≤0.25%

Loss on drying ≤0.5% 0.07%
Sulphated ash ≤0.1% ≤0.05%
Heavy metal ≤20ppm <20ppm
Assay 99.0%~101.0%


Items Requirements Results
Conclusion: This product conforms to the EP7.0 detection.


1.Used to treat dyspepsia and nausea and vomiting caused by functional, organic, infectious, dietary, radiotherapy or drug therapy
2. Gastrointestinal problems
There is some evidence that domperidone has antiemetic activity. Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting. It can be used in patients with Parkinson’s disease because, unlike metoclopramide, domperidone does not cross the blood–brain barrier. Domperidone has also been found effective in the treatment of gastroparesis, a stomach motility condition, and for paediatric gastroesophageal reflux (infant vomiting).
In Canada, the drug is indicated “for the symptomatic management of upper gastrointestinal motility disorders associated with chronic and subacute gastritis and diabetic gastroparesis.” The drug may also be used “to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents”.
The hormone prolactin stimulates lactation in humans, and its release is inhibited by the dopamine secreted by the hypothalamus. Domperidone, by acting as an anti-dopaminergic, results in increased prolactin secretion, and thus promotes lactation.

Packing Detail

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag).
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size:
510mm high, 360mm diameter)

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