Esmolol CAS 81147-92-4

Esmolol, also known as Ailuo, Emolol, Brevibloc, chemical name is 4{[3-[(1-methylethyl)amino]-2hydroxy]propoxy}phenylpropionic acid methyl ester It is a kind of receptor blocker with strong selectivity, fast onset and very short duration of action on the heart.

Its pharmacological effects are: inhibiting the self-discipline of the sinoatrial node, prolonging the conduction of the atrioventricular node, reducing the heart rate, reducing the myocardial contractility, reducing the oxygen consumption, reducing the cardiac load, and having a weak effect on the peripheral vascular resistance.

Esmolol mainly acts on the β1 receptor of the myocardium, and also has a blocking effect on the β2 receptor of the trachea and vascular smooth muscle in large doses. No intrinsic sympathomimetic or membrane stabilizing effects at therapeutic doses. Antiarrhythmic acts mainly by inhibiting the stimulation of adrenaline on the cardiac pacemaker and slowing down the conduction of the atrioventricular node, and its main action site is the sinoatrial node and the atrioventricular node conduction system.

The antihypertensive mechanism of esmolol is not completely clear, and it is similar to propranolol, but when it produces the same β-receptor blocking effect, other selective and non-selective β-blockers such as bimetoprolol and propranolol Receptor blockers are more effective at lowering blood pressure.