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Levomefolate calcium (INN). Also known as L-5-MTHF, L-5-Methyltetrahydrofolate Calcium, is the calcium salt of L-5-methyltetrahydrofolate, belonging to the folic acid group of vitamins (vitamin B9, folic acid), which is a coenzyme form of folic acid.
L-5-Methyltetrahydrofolate (L-5MTHF) is a vitamin B12 derivative found in our body. It acts as a cofactor in the conversion of homocysteine to methionine.
Calcium l-5-methyltetrahydrofolate (5-mthf) is a naturally occurring salt-forming methyl derivative of folic acid. Levomefolate calcium is the most biologically active and functional form of folic acid, which is easier to absorb than ordinary folic acid.
The unmethylated form of folic acid (vitamin B9) is the synthetic form of folic acid, which is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folic acid. It is a methylated derivative of tetrahydrofolate.
Levomefolate calcium is produced by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used for the production of 5,10-methylenetetrahydrofolate (MTHF) by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) also known as methionine synthase ( MS) cycles homocysteine back to methionine.