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Retinoic acid, the molecular formula is C20H28O2, is the metabolic intermediate item of vitamin A in the body, which generally impacts the development of bone and also promotes epithelial cell proliferation, distinction, keratolysis as well as various other metabolic effects.
Chordates call for retinoic acid, including all higher animals from fish to human beings.
It acts through the Hox gene, which ultimately controls the pre/post pattern in early developmental stages.
The critical role of retinoic acid in embryonic development mediates the high teratogenicity of retinoid drugs, such as isotretinoin, which is used to treat cancer and acne.
Oral high doses of preformed vitamin A (retinyl palmitate) and retinoic acid itself have the same teratogenic mechanism.
Retinoic acid is generally made use of in the therapy of acne vulgaris, psoriasis, ichthyosis, lichen planus, pityriasis rubra pilaris, keratosis pilaris, squamous cell carcinoma and cancer malignancy.