1.Verteporfin (brand name Visudyne), a benzoporphyrin derivative, is a drug used as a photosensitizer for photodynamic treatment to treat disorders like the wet type of macular degeneration that are associated with aberrant blood vessels in the eye. When stimulated by nonthermal red light with a wavelength of 689 nm in the presence of oxygen, verteporfin accumulates in these abnormal blood vessels and produces highly reactive, short-lived singlet oxygen and other reactive oxygen radicals, which cause local endothelium damage and block the blood vessels.
2. Off-label usage of verteporfin for the treatment of central serous retinopathy is also practised.
Test Item Standard: USP
Identification IR spectrum similar to that of RS
HPLC retention time similar to that of RS
Related substance Total impurities: NMT0.3%
Single impurity: NMT0.1%
Heavy metals NMT 10ppm
Loss on drying NMT0.5%
Residue on ignition NMT0.1%
Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin. It is used as a photosensitizer for photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration. Verteporfin also suppresses the formation of autophagosome via targeting p62, which binds both polyubiquitinated proteins destined for degradation and LC3 on autophagosomal membranes.